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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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Polyneuropathy due to n -Hexane Intoxication - A Case Series.

Khichar P Shubhakaran1, Pradeep Lalwani, Nidhi Yadav

  • 1Department of Neurology, Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.

Annals of Indian Academy of Neurology
|May 10, 2025
PubMed
Summary

Occupational exposure to n-hexane can cause neurotoxicity. Four patients developed polyneuropathy from n-hexane inhalation, showing nerve damage and improving with symptomatic treatment.

Keywords:
Neuropathyoccupational exposure

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Area of Science:

  • Occupational Medicine
  • Toxicology
  • Neurology

Background:

  • n-Hexane is a volatile organic chemical recognized for its neurotoxic effects.
  • Occupational exposure is a significant route for n-hexane related health issues.

Purpose of the Study:

  • To report on four cases of n-hexane-induced polyneuropathy in a needle manufacturing factory.
  • To describe the clinical presentation, diagnostic findings, and treatment outcomes.

Main Methods:

  • Case series involving four patients with suspected n-hexane neuropathy.
  • Clinical evaluation including cerebrospinal fluid analysis and nerve conduction studies (NCV).
  • Differential diagnosis to exclude other causes of polyneuropathy.

Main Results:

  • Patients presented with polyneuropathy following inhalation exposure to n-hexane.
  • Cerebrospinal fluid analysis revealed albuminocytological dissociation.
  • Nerve conduction studies indicated primary demyelination with secondary axonal damage.
  • All patients showed significant improvement with symptomatic management over six months.

Conclusions:

  • n-Hexane inhalation can lead to demyelinating polyneuropathy.
  • Albuminocytological dissociation and NCV findings are characteristic.
  • Symptomatic treatment is effective for n-hexane neuropathy.