Related Experiment Video
Updated: May 12, 2025

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury
Published on: February 26, 2017
Nebulized Heparin and N-Acetylcysteine do Not Improve Outcomes of Intubated Burn Patients With Grade II or III
William B Risinger1, Victoria R Hammond1, Chinweotuto V Uma1
1Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
None:
Inhalation injuries heighten the morbidity and mortality associated with burn injury. Nebulized heparin and N-acetylcysteine have been proposed as adjunctive treatments for severe inhalation injury. In this study, a total of 100 inhalation injuries were identified over a 4-year period, with 40 patients suffering grade II-III inhalation injuries confirmed via fiberoptic bronchoscopy. 47.5% of patients received the inhalation protocol of nebulized heparin, N-acetylcysteine, and albuterol. Patient demographics and inhalation injury grade were similar between the groups (2 vs 2, P = .20). The utilization of the inhalation protocol did not shorten the number of ventilator days (5 vs 6, P = .76) or show survival benefit (57.9 vs 52.4%, P = .73). An inhalational protocol did not improve outcomes in burn patients suffering abbreviated injury score (AIS) grade II-III inhalation injuries at our institution. Moving forward, large, multicenter, randomized control trials are needed to determine the true efficacy of nebulized heparin and N-acetylcysteine for AIS grade II-III injuries.
More Related Videos
02:49Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
Published on: February 23, 2024
09:36Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Related Concept Videos
Endotracheal Intubation II: Nursing Management
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
Flail Chest-II
Assessment:
1. Clinical Evaluation:
History:
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...