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Hibernation "trigger" alters renal function in the primate.

P R Oeltgen, R A Blouin, W A Spurrier

    Physiology & Behavior
    |January 1, 1985
    PubMed
    Summary
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    Woodchuck hibernation trigger (HT) albumin fraction significantly reduced primate kidney function, impacting creatinine clearance and urine flow. This suggests HT directly affects primate renal mechanisms beyond hibernation

    Area of Science:

    • Comparative physiology
    • Renal physiology
    • Hibernation biology

    Background:

    • Woodchucks exhibit physiological changes during hibernation.
    • Albumin fractions may influence renal function.
    • Primate renal responses to animal hibernation factors are not well understood.

    Purpose of the Study:

    • To investigate the effect of woodchuck plasma albumin fractions from different physiological states on primate renal function.
    • To determine if the hibernation trigger (HT) albumin fraction has a direct impact on kidney function in macaques.

    Main Methods:

    • Macaque monkeys were surgically prepared with venous and urinary catheters.
    • Basal urine production and creatinine clearance were measured.
    • Intravenous administration of woodchuck plasma albumin fractions (HT and SAWA) was performed.

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  • Renal function parameters were monitored post-infusion.

    • Main Results:

    • The summer active (SAWA) albumin fraction had no effect on renal function.
    • The hibernation trigger (HT) albumin fraction significantly reduced creatinine clearance.
    • A trend towards decreased urine flow and creatinine production was observed after HT infusion.

    Conclusions:

    • The woodchuck hibernation trigger (HT) albumin fraction exerts a direct action on primate kidney function.
    • HT may influence glomerular filtration and tubular reabsorption processes.
    • These findings suggest a specific renal effect of hibernation-associated factors beyond general metabolic depression.