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Published on: April 27, 2013
New ecdysteroids with anticomplementary activity from roots of Leuzea uniflora (L.) holub
Wen-Qing Du1, Can Liu1, Ruo-Mei Li1
1Chemical R&D, School of Pharmaceutical Sciences, Hebei Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang, China.
Abstract:
Phytochemical investigation on roots extract of Leuzea uniflora (L.) Holub led to the isolation of two novel ecdysteroids, 11α-hydroxy-25R-inokosterone (1) and 11α-hydroxy-24R, 25 R-amarasterone A (2), along with 20 known constituents. The structures of novel compounds were confirmed by NMR and ECD spectroscopy. Compounds 2 and 9 exhibited anticomplementary activity with classical pathway, their CH50 values were 138.4 ± 0.07 µg·mL-1 and 158.3 ± 0.09 µg·mL-1, respectively.

