Vascular embolic nanobiomaterials for efficient tumor treatment

Embolization is a minimally invasive cancer treatment method. Embolization involves artificially blocking blood flow using an embolic agent to block abnormal blood vessels that supply nutrients or oxygen to a specific lesion, thereby killing the lesion, inhibiting its growth, and stopping bleeding. Currently, polyvinyl alcohol (PVA) and gelatin are the most popular embolic agents. These substances are available in various sizes and shapes that physically obstruct blood flow to cause vascular embolization. They are commonly used due to their ease of use and low cost. However, they can cause side-effect such as bleeding and potential complications related to catheter- and insertion-related complications. Recently, nanobiomaterials have been explored as embolization agents with high biocompatibility, such as liquid metals, and can be used with autologous blood. In this review, we cover the types of embolic agents currently used in cancer treatment and focus on those with fewer adverse effects and minimal vascular damage, followed by discussions on new embolic agents under development. Additionally, we explore potential future research directions for developing better embolic agents.