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Updated: May 13, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
IL17RA genetic variants are associated with susceptibility and severity of psoriasis
Camila Cataldi de Alcantara1, Edna Maria Vissoci Reiche2, Cássio Rafael Moreira3
1Laboratory of Research in Applied Immunology, State University of Londrina, Londrina, PR, Brazil; Postgraduate Program of Laboratorial and Clinical Physiopathology, State University of Londrina, Londrina Brazil.
Background:
Genetic variants that can play an important role in psoriasis (PsO) ethiology and pathophysiology.
Objective:
To evaluate the association between the IL17RA genetic variants with the susceptibility and severity of PsO.
Methods:
This study included 154 patients with PsO and 154 healthy controls. The severity of PsO was determined using Psoriatic Activity and Severity Index (PASI). The IL17RA single nucleotide variants T > C rs2241043, A > G rs2241049, and G > A rs6518661 were genotyped.
Results:
The IL17RA A > G (rs2241049) GG genotype was associated with protection against PsO [odds ratio (OR): 0.391, 95 % confidence interval (CI):0.199-0.768, p = 0.006)] while the IL17RA T > C (rs2241043) CC genotype and the IL17RA G > A (rs6518661) AA genotype were associated with the PsO severity (OR = 0.30, 95 % CI 0.10-0.093, p = 0.020 and OR = 0.22, 95 % CI 0.05-0.99, p = 0.020, respectively).
Conclusion:
The results demonstrated that the IL17RA A > G (rs2241049) GG genotype may be a protective factor against the development of PsO and the CC genotype of the IL17RA T > C (rs2241043) and the AA genotype of the IL17RA G > A (rs6518661) variants were associated with protection against the severity of PsO. Considering that these variants are located in intronic regions of the IL17RA, other genetic and epigenetic mechanisms involved in these associations should be investigated.
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