Related Experiment Video
Updated: May 13, 2025

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Effects of PDYN 68-bpVNTR, BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 polymorphisms on opioid-methamphetamine
Merve Ak1, Gizem Özer-Uzaldı1, Mukaddes Asena Yıldırım2
1Ankara University, Graduate School of Health Sciences, Ankara, Türkiye; Ankara University, Institute of Forensic Sciences, Ankara, Türkiye.
Abstract:
To investigate the impact of PDYN 68-bpVNTR, BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 variations on the susceptibility to opioid-methamphetamine co-use, a total of 532 individuals, including opioid (n = 104), and methamphetamine (n = 166) users as well as opioid and methamphetamine co- users (n = 158) and healthy individuals (n = 104), were included. BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 were genotyped by PCR-RFLP method, while PDYN 68-bp VNTR was genotyped by PCR. The assessment of impulsiveness, craving, withdrawal, anxiety and depressive symptoms was conducted using scales. A significant difference was identified between the substance-using groups and the control group in view of the alleles of PDYN 68-bp VNTR (p = 0.001). The allele frequencies of the PDYN 68-bp VNTR exhibited a difference between opioid and methamphetamine users (p = 0.018). The 5-repeat allele was first observed in the Turkish population. The analysed polymorphisms could contribute to the development of addiction, exerting an influence on impulsiveness, craving and withdrawal.
More Related Videos
09:29Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
07:05Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
Published on: September 10, 2018
Related Concept Videos
Opioid Receptors: Overview
Drug Abuse and Addiction: Pharmacological Phenomena
Drugs Affecting Neurotransmitter Synthesis
Opioid Analgesics: Synthetic and Semisynthetic Opioids
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Analgesia and Pain Management