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Related Experiment Video

Updated: May 13, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Aging with HIV: a cross-sectional look at comorbidities.

M C Montes1, J A Rueda-Camino2, N Rallón3

  • 1Internal Medicine Department, Hospital Universitario Rey Juan Carlos, 28933 Móstoles, Madrid, Spain.

Revista Clinica Espanola
|May 10, 2025
PubMed
Summary

Older adults living with HIV (PLHIV) experience a high burden of non-infectious comorbidities and geriatric syndromes. This multimorbidity significantly increases with age in this population.

Keywords:
ComorbiditiesComorbilidadesElderly peopleEnvejecimientoHIVPeople living with HIVPersonas que viven con VIHPrevalencePrevalenciaVIH

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Area of Science:

  • Geriatric Medicine
  • Infectious Diseases
  • Public Health

Background:

  • People living with HIV (PLHIV) face a higher risk of developing multiple health conditions (multimorbidity) than the general population.
  • Aging PLHIV populations require specific attention due to increased vulnerability to non-infectious diseases and geriatric syndromes.

Purpose of the Study:

  • To determine the prevalence of non-infectious comorbidities in PLHIV aged 50 and older.
  • To evaluate the occurrence of geriatric syndromes in this demographic.
  • To analyze trends in comorbidity and multimorbidity across different age groups.

Main Methods:

  • Cross-sectional analysis of PLHIV aged 50+ from a Spanish University Hospital outpatient clinic.
  • Categorization of participants into ten-year age intervals.
  • Estimation of crude and standardized prevalence for comorbidities, geriatric syndromes, and multimorbidity (≥2 diseases) using exact methods.

Main Results:

  • Multimorbidity was prevalent in 37% of PLHIV over 50.
  • Most common comorbidities included dyslipidemia (37.7%), hypertension (26.2%), diabetes mellitus (14.8%), and non-AIDS defining cancers (15.6%).
  • Frequent geriatric syndromes were fractures/osteoporosis (9.8%), dementia (8.2%), and frailty (8.2%); prevalence increased with age.

Conclusions:

  • PLHIV over 50 exhibit a high prevalence of non-infectious comorbidities and geriatric syndromes.
  • Age is a significant factor, with multimorbidity increasing in older PLHIV.
  • These findings highlight the need for comprehensive geriatric care in aging HIV populations.