Related Experiment Video
Updated: Jun 13, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
Published on: August 18, 2023
Evaluating dosing accuracy and galenic dispersion quality in Hospital-Based pediatric spironolactone oral suspension
Roxanne Desquines1, Romain Gallissot2, Caroline Viard1
1University Hospital Centre Toulouse, Department of Pharmacy, France.
Abstract:
Compounded oral suspensions of spironolactone are commonly used in pediatric patients with heart conditions. However, due to its poor solubility in water, spironolactone suspensions may lead to sedimentation, compromising homogeneity and dose accuracy. This study aimed to assess dose accuracy of spironolactone suspension in critical care settings. Over one month in 2020 and 2022, samples prepared by nurses in Pediatric (PICU) and Neonatal Intensive Care Units (NICU) were collected and analysed using an HPLC/UV validated method to evaluate dose deviations from target. Educational interventions on suspension preparation were conducted between the two periods. In 2020, only 28% (NICU) and 0% (PICU) of samples met target dose with greater variability in PICU. After educational intervention from the pharmacy teams, in 2022 improvements were observed, but underdosing and variability remained significant, reflecting ongoing challenges in suspension homogeneity. These findings highlight the need for a more stable pediatric formulation to enhance patient safety and treatment effectiveness.
Related Concept Videos
Factors Affecting Drug Response: Overview
Rational Dosage Regimen: Maintenance Dose and Loading Dose
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Drug Dosage Regimen: Overview
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...

