Genomics of Attention Deficit Hyperactivity Disorder: What the Clinician Needs to Know

This report provides an update on current knowledge and applications of genomic research in attention deficit hyperactivity disorder (ADHD). The history, principles, and underlying assumptions for genetic studies on psychiatric disorders are reviewed. Recent DNA sequencing and genome-wide association studies have revealed common and rare genetic variants associated with ADHD. Communication of genetic knowledge in meetings with patients and their relatives and common misconceptions are addressed. The importance of recognizing genetic syndromes masquerading as ADHD or other common psychiatric disorders is emphasized and how genetic information can be used to improve diagnosis and therapy are discussed.