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Updated: Jun 9, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Recurrent headache mimicking cluster headache: a diagnostic challenge
Qing Wan1, Jiayu Wu2, Ting Zhang3
1Emergency Department, Shanghai United Family Hospital, 699 Pingtang Road, Changning District, Shanghai, 200335, China.
Abstract:
A 37-year-old man presented with recurrent, severe left-sided headaches occurring at the same time each evening, accompanied by ipsilateral lacrimation, conjunctival injection, and nasal congestion. The clinical features were suggestive of cluster headache (CH), but poor response to high-flow oxygen and triptans raised concern for a secondary cause. Neuroimaging revealed an ethmoid sinus mucocele with adjacent bone remodeling, mimicking trigeminal autonomic cephalalgia. Surgical drainage led to complete symptom resolution, suggesting a secondary headache etiology. This case highlights the need to consider structural causes in atypical or treatment-resistant headache presentations and the importance of neuroimaging in accurate diagnosis and management.
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