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Updated: May 14, 2025
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Methodology for Accurate Detection of Mitochondrial DNA Methylation
Published on: May 20, 2018
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Maternal asthma and newborn DNA methylation.
Casper-Emil Tingskov Pedersen1, Thanh T Hoang2,3,4,5, Jianping Jin2
1Copenhagen Prospective Studies On Asthma in Childhood, Herlev and Gentofte Hospital, COPSAC, University of Copenhagen, Ledreborg Alle 34 Gentofte, 2820, Copenhagen, Denmark.
Clinical Epigenetics
|May 10, 2025
Summary
Maternal asthma during pregnancy may alter newborn DNA methylation patterns, potentially influencing childhood asthma susceptibility. This study explored the links between parental asthma and epigenetic changes in newborns.
Area of Science:
- Epigenetics
- Genomics
- Pediatric Health
Background:
- Prenatal exposure to maternal asthma may impact offspring DNA methylation.
- These epigenetic alterations could influence susceptibility to diseases like asthma later in life.
Purpose of the Study:
- To investigate the association between parental asthma and DNA methylation in newborn blood.
- To identify specific DNA methylation sites and regions linked to maternal and paternal asthma.
Main Methods:
- Epigenome-wide association analyses (EWAS) were performed on 7433 newborns using Illumina450K or EPIC arrays.
- Fixed effects meta-analyses identified differentially methylated CpGs (DMCs) and regions (DMRs).
- Gene expression analyses examined associations with publicly available data from children and adults.
Main Results:
- 27 CpGs and 5 DMRs were associated with maternal asthma during pregnancy.
- Two CpGs and 13 DMRs were linked to paternal asthma.
- Maternal asthma-associated DMCs showed links to gene expression, including HLA genes and HOXA5, in blood and lung tissues.
Conclusions:
- Parental asthma, particularly maternal asthma during pregnancy, is associated with altered newborn DNA methylation.
- These epigenetic modifications may contribute to the underlying mechanisms of asthma susceptibility in offspring.
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