Penile Cancer: Differences Between Patients Over and Under the Age of 75 Years
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View abstract on PubMed
Summary
This summary is machine-generated.Older penile cancer patients (≥75 years) had worse survival, especially in stage 3 disease. This may be due to poorer health status and less aggressive treatment in this age group.
Area Of Science
- Oncology
- Geriatric Medicine
- Surgical Oncology
Background
- Penile cancer disproportionately affects older men.
- Limited data exists on age-related differences in penile cancer treatment and outcomes.
Purpose Of The Study
- To compare patient characteristics, treatment approaches, and cancer-specific survival in penile cancer patients aged 75 years and older versus those younger than 75 years.
Main Methods
- Retrospective analysis of 196 penile cancer patients treated between 2009 and 2020 across 12 hospitals.
- Comparison of outcomes between patients aged ≥75 years (n=80) and <75 years (n=116).
Main Results
- Older patients (≥75 years) with clinical stage 3 penile cancer had significantly worse cancer-specific survival.
- The older group presented with poorer Eastern Cooperative Oncology Group Performance Status, lower albumin, and higher neutrophil-to-lymphocyte ratios.
- Less aggressive treatments, including partial penile resection and less frequent pelvic lymph node dissection, were observed in older patients.
Conclusions
- Advanced age (≥75 years) is associated with poorer cancer-specific survival in penile cancer, particularly for stage 3 disease.
- Compromised performance status and reduced treatment intensity in older patients may contribute to inferior survival outcomes.
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