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Penile Cancer: Differences Between Patients Over and Under the Age of 75 Years.

Yoji Murakami1, Takahiro Yamaguchi2, Masato Goya3

  • 1Department of Urology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan.

International Journal of Urology : Official Journal of the Japanese Urological Association
|May 11, 2025
PubMed
Summary
This summary is machine-generated.

Older penile cancer patients (≥75 years) had worse survival, especially in stage 3 disease. This may be due to poorer health status and less aggressive treatment in this age group.

Keywords:
cancer‐specific survivalelderly patientoutcomespenile cancertreatment selection

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Area of Science:

  • Oncology
  • Geriatric Medicine
  • Surgical Oncology

Background:

  • Penile cancer disproportionately affects older men.
  • Limited data exists on age-related differences in penile cancer treatment and outcomes.

Purpose of the Study:

  • To compare patient characteristics, treatment approaches, and cancer-specific survival in penile cancer patients aged 75 years and older versus those younger than 75 years.

Main Methods:

  • Retrospective analysis of 196 penile cancer patients treated between 2009 and 2020 across 12 hospitals.
  • Comparison of outcomes between patients aged ≥75 years (n=80) and <75 years (n=116).

Main Results:

  • Older patients (≥75 years) with clinical stage 3 penile cancer had significantly worse cancer-specific survival.
  • The older group presented with poorer Eastern Cooperative Oncology Group Performance Status, lower albumin, and higher neutrophil-to-lymphocyte ratios.
  • Less aggressive treatments, including partial penile resection and less frequent pelvic lymph node dissection, were observed in older patients.

Conclusions:

  • Advanced age (≥75 years) is associated with poorer cancer-specific survival in penile cancer, particularly for stage 3 disease.
  • Compromised performance status and reduced treatment intensity in older patients may contribute to inferior survival outcomes.