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Updated: May 13, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
AI Applications in Transfusion Medicine: Opportunities, Challenges, and Future Directions
Merav Barzilai1, Omri Cohen2,3, Omri Cohen2,3
1Blood Services and Apheresis Institute, Rabin Medical Center and Tel Aviv University, Tel Aviv, Israel.
Artificial intelligence (AI) is transforming transfusion medicine by improving donor management, blood quality, and patient safety. Addressing challenges like data privacy and bias is key to realizing AI's full potential in healthcare.
Area of Science:
- Healthcare Technology
- Medical Informatics
- Hematology
Background:
- Transfusion medicine faces persistent challenges in efficiency, safety, and resource allocation.
- Artificial intelligence (AI) offers novel solutions to these longstanding issues.
- AI integration, including Machine Learning (ML), Deep Learning, Natural Language Processing (NLP), and predictive analytics, is rapidly advancing.
Purpose of the Study:
- To review the diverse applications of AI in transfusion medicine.
- To highlight AI's potential to enhance operational efficiency and patient outcomes.
- To discuss challenges and future directions for AI implementation in this field.
Main Methods:
- Review of current AI applications in transfusion medicine domains.
- Analysis of AI's role in donor management, blood product optimization, and risk prediction.
- Exploration of AI in antigen phenotyping, hemovigilance, and inventory management.
Main Results:
- AI demonstrates potential in improving donor management, blood product quality, and predicting transfusion needs.
- AI tools enhance patient safety by assessing bleeding risks and enabling accurate blood antigen phenotyping.
- AI streamlines operations through automated hemovigilance and advanced inventory forecasting.
Conclusions:
- AI integration shows significant promise for improving patient outcomes and advancing precision medicine in transfusion services.
- Addressing challenges like algorithmic transparency, data privacy, bias, and equitable access is crucial for responsible AI adoption.
- Future research should focus on scalable AI models, federated learning, and AI-driven clinical trials to redefine transfusion medicine globally.
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