Occurrence of pharmaceuticals, illicit drugs and PFAS in global surface waters: A meta-analysis-based review
Joshua R Monk1, Peter S Hooda2, Rosa Busquets3
1School of Engineering and the Environment, Kingston University, London, UK; College of Southern Nevada, Las Vegas, NV, USA.
Abstract:
Emerging contaminants (ECs) have been recognized as a new class of water contaminants and their occurrence in surface water is a concern for ecosystems and society. The aim of this study is to provide a comprehensive systematic review based meta-analysis of ECs in global surface waters and associated ecological risks. With a special focus on pharmaceuticals and illicit drugs (PIDs), and per- and polyfluoroalkyl substances (PFAS). Web of Science, Scopus, Google Scholar, and PubMed databases were screened to retrieve articles published between 2013 and 2024. One hundred-one articles comprising 714 datasets spanning 70 PIDs and PFASs in surface water across 46 countries were included in the meta-analysis study. Global PID concentrations ranged from 0.02 ng/L to 82,188 ng/L, with metformin (MFN) having the highest meta-analyzed median concentration of 729.4 ng/L. Antibiotics, analyzed separately revealed sulfonamides as the most detected. Our analysis showed that PIDs (including antibiotics) levels were in the upper quartiles in low-income settings where wastewater treatment is scarce, whereas in most situations where secondary treatments are utilized, their levels tended to remain in the lower quartile. Wastewater treatment beyond a secondary level can reduce these chemicals to levels which present little to no environmental impact. Global PFAS concentrations ranged from 0.01 ng/L to 311.25 ng/L with perfluoroalkylcarboxylic acids (PFCAs) being the most commonly occurring PFAS. Meta-analysis revealed that perflurohexanoic acid (PFHxA) had the highest meta-synthesized median concentration of 3.6 ng/L in surface waters. Environmental risk assessment revealed high risk (HQ ≥ 1) for the following: MFN, acetaminophen (APAP), ibuprofen (IBU), sulfacetamide (SAM) and lomefloxacin (LFX) and moderate risk (HQ ≥ 0.1) for perfluorododecanoic acid (PFDoA), perfluorotetradecanoic acid (PFTeDA) and perfluoroundecanoic acid (PFUnDA).
More Related Videos
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
07:06Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique
Published on: September 28, 2022
Related Concept Videos
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Drug Control Governance: Regulatory Bodies and Their Impact
Pharmaceutical Poisoning: Potential Scenarios
Microbial Bioremediation of Pesticides
