Ewing's sarcoma in pregnancy

Here is a case of a woman in her mid-20s, with primary infertility for a duration of 6 years with irregular cycles, following which she spontaneously conceived. Unaware of her pregnancy status, she underwent concurrent radiotherapy and chemotherapy for extraosseous Ewing's sarcoma. During the workup following treatment of Ewing's sarcoma, she underwent ultrasonographic examination, which showed a single, live intrauterine gestation. The pregnancy was terminated due to cytotoxic effects of the chemoradiation. Treatment of Ewing's sarcoma involves a combination of surgery, chemotherapy and radiotherapy. In pregnant women with Ewing's sarcoma, a multidisciplinary approach is needed to diagnose and treat the condition. Any form of teratogenic drug or radiation exposure during the first trimester and early second trimester can have potential damage on the fetus.