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Prognostic Value of Multiple Circulating Biomarkers for Ventricular Arrhythmias in Left Ventricular

Limin Liu1, Le Li1, Simin Cai2

  • 1Cardiac Arrhythmia Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.

Circulation Journal : Official Journal of the Japanese Circulation Society
|May 11, 2025
PubMed

Insights

Big endothelin-1 levels predict ventricular arrhythmias (VA) in patients with left ventricular hypertrabeculation (LVHT). Elevated big endothelin-1 and specific hypertrabeculation locations increase VA risk, aiding in patient risk stratification.

Area of Science:

  • Cardiology
  • Biomarkers
  • Genetics

Background:

  • Ventricular arrhythmia (VA) is a significant risk factor for adverse outcomes in patients with left ventricular hypertrabeculation (LVHT).
  • Identifying predictive biomarkers for VA in LVHT is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the predictive value of various biomarkers for the occurrence of ventricular arrhythmias in patients diagnosed with left ventricular hypertrabeculation.
  • To explore the association between big endothelin-1 concentrations and VA risk in the LVHT cohort.

Main Methods:

  • Retrospective cohort study of 265 LVHT patients.
  • Analysis of baseline biomarkers including N-terminal pro B-type natriuretic peptide, big endothelin-1, hs-CRP, uric acid, and free fatty acid.
  • Multivariable Cox regression and restricted cubic spline analyses to assess VA prediction.

Main Results:

  • 82 (30.9%) patients experienced VAs over a median follow-up of 4.34 years.
  • Elevated big endothelin-1 concentrations were independently associated with an increased risk of VAs (HR 1.513, P=0.005).
  • Higher big endothelin-1 levels, particularly >0.63 pmol/L, especially with cardiomyopathies or specific LV dimensions/function, indicated closer monitoring for VAs.

Conclusions:

  • Big endothelin-1 concentrations serve as an independent predictor of VA in LVHT patients.
  • The location of hypertrabeculation, in conjunction with big endothelin-1 levels, enhances risk stratification for VAs in this population.
Abstract

Keywords:
Big endothelin-1BiomarkerLeft ventricular hypertrabeculationVentricular arrhythmia

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