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Vanadia Nanozymes Inhibit Platelet Aggregation, Modulate Signaling Pathways and Prevent Pulmonary Embolism in Mice.

G R Sherin1, Bidare N SharathBabu1, Kurnegala Manikanta2

  • 1Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India.

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|May 11, 2025
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Summary

New vanadium oxide (V2O5) nanozymes effectively inhibit platelet aggregation and prevent blood clots without causing bleeding. These antioxidant nanozymes show promise as safe and effective antithrombotic agents for treating thrombosis.

Keywords:
Glutathione peroxidaseNanozymesPlateletsPulmonary embolismThrombosis

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Hematology

Background:

  • Thrombosis, including deep vein thrombosis and pulmonary embolism, is a significant concern, especially in COVID-19 patients.
  • Platelets are critical in hemostasis and thrombosis, making platelet aggregation inhibitors vital for treating thrombotic disorders.
  • Glutathione peroxidase (GPx) is known to prevent platelet-dependent thrombosis.

Purpose of the Study:

  • To investigate antioxidant nanozymes, specifically vanadium oxide (V2O5), for their potential to inhibit platelet activation and aggregation.
  • To evaluate the antithrombotic efficacy and safety of V2O5 nanozymes.

Main Methods:

  • Studied a series of antioxidant nanozymes for their ability to inhibit platelet aggregation.
  • Assessed V2O5 nanozymes for morphology-dependent glutathione peroxidase (GPx) activity.
  • Evaluated the inhibition of human platelet aggregation in vitro.
  • Tested the prevention of pulmonary thromboembolism in a mouse model.

Main Results:

  • V2O5 nanozymes demonstrated morphology-dependent GPx activity.
  • These nanozymes effectively inhibited human platelet aggregation.
  • V2O5 nanozymes successfully prevented pulmonary thromboembolism in mice.
  • No adverse bleeding side effects were observed.

Conclusions:

  • V2O5 nanozymes are effective inhibitors of platelet aggregation and possess antithrombotic properties.
  • These nanozymes represent a promising new class of safe and effective antithrombotic agents.
  • The findings support the development of nanozyme-based therapies for thrombotic diseases.