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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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[Research progress of long noncoding RNA in atopic dermatitis].

Xin Liu1, Xinying Cai

  • 1Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China. caixinying0913@126.com.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|May 11, 2025
PubMed
Summary

Long noncoding RNAs (lncRNAs) are increasingly implicated in atopic dermatitis (AD). Research highlights their abnormal expression in AD patients, suggesting novel therapeutic targets for this chronic inflammatory skin condition.

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Area of Science:

  • Molecular Biology
  • Dermatology
  • Immunology

Background:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease with complex pathogenesis.
  • Key factors in AD include genetic susceptibility, impaired skin barrier function, and immune system dysregulation.
  • Long noncoding RNAs (lncRNAs), RNA molecules longer than 200 nucleotides that do not encode proteins, are recognized for their roles in various diseases.

Purpose of the Study:

  • To review current research on the involvement of lncRNAs in the pathogenesis of atopic dermatitis.
  • To summarize the abnormal expression patterns of lncRNAs observed in AD patients.
  • To provide insights into the potential of lncRNAs as therapeutic targets for AD.

Main Methods:

  • Literature review of studies investigating lncRNA expression and function in atopic dermatitis.
  • Analysis of research findings on the role of specific lncRNAs in AD development.
  • Synthesis of information regarding the connection between lncRNA dysregulation and AD pathology.

Main Results:

  • Numerous lncRNAs have been found to be abnormally expressed in patients with atopic dermatitis.
  • These dysregulated lncRNAs are involved in the intricate mechanisms driving AD development.
  • Evidence suggests lncRNAs contribute to the inflammatory processes characteristic of AD.

Conclusions:

  • Abnormal lncRNA expression is a significant factor in the pathogenesis of atopic dermatitis.
  • lncRNAs represent promising biomarkers and potential therapeutic targets for managing AD.
  • Further research into lncRNA function in AD could lead to novel treatment strategies.