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Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

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Published on: June 13, 2011

The interictal transcriptomic map of migraine without aura.

Peter Petschner^1,2,3,4,5, Sahel Kumar^6,7, Duc A Nguyen^8,9

¹Bioinformatics Center, Institute of Chemical Research, Kyoto University, Uji, Kyoto, 611 - 0011, Japan. petschner.peter@semmelweis.hu.

The Journal of Headache and Pain

|May 11, 2025

Summary

This study maps migraine without aura (MO) transcriptomics, revealing downregulated metabolic, cardiovascular, and immune pathways. Novel drug candidates like tetrandrine and probucol were identified for potential MO treatment.

Keywords:

Drug discovery Molecular pathophysiology Genomics Migraine without aura Transcriptomics

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Published on: December 6, 2016

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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Area of Science:

Genomics
Transcriptomics
Pharmacology

Background:

Migraine without aura (MO) represents a significant neurological disorder with complex underlying mechanisms.
Existing research lacks a replicable transcriptomic map to guide future investigations and clinical strategies.

Purpose of the Study:

To establish a reproducible transcriptomic profile of MO.
To conduct comprehensive genomic and drug discovery analyses for novel research and clinical hypotheses.

Main Methods:

Recruited 22 MO patients and 30 controls, performing interictal RNA-sequencing at two time points.
Conducted genetic association studies using UK Biobank and cohort data.
Employed molecular docking and machine learning to predict drug-protein interactions for identified transcriptomic changes.

Main Results:

Identified CYP26B1 as a key molecular alteration in MO.
Discovered 88 downregulated pathways (metabolic, cardiovascular, immune) and 69 key genes (e.g., CORIN).
Found significant LRP1 polymorphisms linked to vitamin A signaling, suggesting a novel etiology, and predicted tetrandrine and probucol as potential therapeutics.

Conclusions:

Established a replicable transcriptomic map of MO, elucidating molecular pathomechanisms.
Reported key gene-level findings and proposed LRP1-mediated retinoic acid signaling as a novel etiological factor.
Delivered potential new drug candidates for migraine treatment.