Related Experiment Video

Updated: May 15, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.6K

Vitamin D status, vitamin D receptor polymorphisms, and risk of cardiometabolic multimorbidity

Jianhua Ma1,2, Pingan Li1,2, Jinqi Wang1,2

  • 1School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, Beijing, 100069, China.

Nutrition Journal
|May 11, 2025
PubMed

Insights

Adequate vitamin D levels and specific vitamin D receptor (VDR) gene variants can reduce cardiometabolic disease (CMD) risk and slow progression to cardiometabolic multimorbidity (CMM) or death. VDR polymorphisms may personalize prevention strategies for CMM.

Area of Science:

  • Endocrinology
  • Genetics
  • Public Health

Background:

  • Cardiometabolic multimorbidity (CMM) prevalence is rising.
  • Vitamin D and VDR polymorphisms are linked to individual cardiometabolic diseases (CMD).
  • The role of vitamin D and VDR in CMM progression and mortality is not well understood.

Purpose of the Study:

  • To investigate associations between vitamin D, VDR polymorphisms, and CMM progression dynamics.
  • To explore how VDR polymorphisms modify the effects of vitamin D on CMM progression.

Main Methods:

  • Utilized UK Biobank data from 396,192 participants.
  • Defined CMM as co-occurrence of at least two CMDs (T2D, CHD, stroke).
  • Employed a multi-state model to analyze serum 25(OH)D and VDR polymorphism associations with CMM progression.

Main Results:

  • Higher serum 25(OH)D (≥75 nmol/L) correlated with reduced risk for baseline to first CMD, first CMD to CMM, and baseline to death.
  • L-shaped associations observed, with a potential threshold around 45 nmol/L for vitamin D.
  • Specific VDR polymorphisms (rs1544410 T alleles detrimental; rs11568820 T alleles protective) and their interaction with vitamin D levels were identified.

Conclusions:

  • Maintaining adequate vitamin D levels is crucial for reducing CMD risk and delaying CMM or death.
  • VDR polymorphisms can modify vitamin D's effects, enabling risk stratification.
  • Personalized prevention strategies for CMM can be developed based on VDR genotype and vitamin D status.
Abstract

Keywords:
Cardiometabolic MultimorbidityVitamin DVitamin D receptor polymorphisms

More Related Videos

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

11.6K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K

Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
506
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
20
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
38
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
4.9K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.2K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
13.7K