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Real-world disease burden and planned treatment optimization after MANAGE-PD implementation in Germany: a
Martin Südmeyer1,2, David J Pedrosa3, Frank Siebecker4
1Department of Neurology, Ernst-Von-Bergmann Klinikum, Charlottenstr. 72, 14467, Potsdam, Germany. martin.suedmeyer@klinikumevb.de.
Neurological Research and Practice
|May 11, 2025
Summary
The MANAGE-PD tool effectively identifies advanced Parkinson's disease (PD) patients with higher disease burden. Despite this, treatment optimization, including device-aided therapies (DAT), is often delayed, highlighting a gap in care for PD patients.
Area of Science:
- Neurology
- Movement Disorders
- Clinical Research
Background:
- Parkinson's disease (PD) treatment optimization in Germany is often conservative.
- The MANAGE-PD tool aids in identifying advanced PD patients and guiding decisions on device-aided therapies (DAT).
Purpose of the Study:
- To assess the real-world disease burden in advanced Parkinson's disease (PD).
- To evaluate treatment optimization strategies following the implementation of the MANAGE-PD tool in Germany.
Main Methods:
- A prospective, non-interventional study involving 278 adult PD patients in Germany.
- Disease burden assessed via UPDRS, NMSS, and PDQ-8. Treatment changes and MANAGE-PD categories were analyzed.
Main Results:
- Lower MANAGE-PD categories correlated with worse motor/non-motor symptoms and quality of life.
- Over 50% of patients inadequately controlled did not have planned oral treatment changes.
- A significant percentage of patients who could benefit from DAT did not receive it, with patient decisions cited as a barrier.
Conclusions:
- The MANAGE-PD tool demonstrates validity by correlating with disease burden.
- Timely information is crucial for informed patient decisions regarding advanced Parkinson's disease (PD) treatment optimization.
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