[Neurological Peroxisomal Disorders with a Focus on Adrenoleukodystrophy]

Peroxisomal disorders include hereditary neurological diseases, such as adrenoleukodystrophy, peroxisome biogenesis disorders, and β-oxidation enzyme deficiencies. Early diagnosis of adrenoleukodystrophy is critical, as early hematopoietic stem cell transplantation is effective even in the adult cerebral form. With the expansion of largescale genetic analyses, peroxisomal diseases presenting with symptoms, such as cerebellar ataxia, have also been identified in adult patients. This article focuses on the early diagnosis of peroxisomal neurological diseases.