[New strategy and method in traditional Chinese medicine compatibility for detoxification based on...

Area of Science:

• Pharmacology
• Toxicology
• Herbal Medicine

Context:

• Traditional Chinese Medicine (TCM) safety is paramount, with established theories for intrinsic toxicity.
• Recent understanding reveals idiosyncratic and indirect toxicities in TCM, challenging traditional safety models.
• Existing TCM safety strategies are insufficient for newly identified toxicities.

Purpose:

• To propose a new TCM compatibility strategy for detoxification based on component-target-effect interactions.
• To align TCM compatibility with modern cognitive theories of toxicity.
• To ensure the safe and precise clinical application of TCM.

Summary:

• A novel strategy for TCM compatibility focuses on component-target-effect interactions to achieve detoxification.
• This approach blocks drug-mediated damage and promotes repair through interactions at the component, target, and effect levels.
• The strategy has been applied to reduce the toxicity of specific TCM herbs and elucidate mechanisms of action.

Impact:

• Provides a theoretical and methodological basis for safe and precise TCM use.
• Innovates TCM compatibility theories and detoxification methods.
• Supports the development of risk prevention and control countermeasures for diverse TCM toxicities.