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Related Experiment Videos

Propionate loading test for liver function in spontaneously ketotic dairy cows.

Y Gröhn

    Research in Veterinary Science
    |July 1, 1985
    PubMed
    Summary

    Ketotic dairy cows show impaired propionate utilization, leading to delayed glucose production and slower ketone body reduction after sodium propionate loading. This impacts liver function in cows with ketosis.

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    Area of Science:

    • Veterinary Medicine
    • Animal Physiology
    • Metabolic Diseases

    Background:

    • Ketosis is a common metabolic disorder in dairy cows.
    • Impaired propionate utilization by the liver contributes to ketosis.
    • Understanding glucose and ketone body metabolism is crucial for managing ketosis.

    Purpose of the Study:

    • To investigate hepatic propionate utilization in spontaneously ketotic dairy cows.
    • To compare glucose and ketone body responses to propionate loading in control and ketotic cows.
    • To assess the impact of ketosis severity on metabolic responses.

    Main Methods:

    • Intravenous sodium propionate loading (2.5 mmol kg-1) in dairy cows.
    • Measurement of plasma glucose and blood ketone body concentrations (acetoacetate, beta-hydroxybutyrate).
    • Categorization of cows into control, mildly ketotic, and severely ketotic groups based on acetoacetate levels.

    Main Results:

    • Plasma glucose increased significantly in all groups post-injection, with a faster peak in controls.
    • Glucose concentration changes differed significantly between control and ketotic cows from 20 minutes onwards.
    • Acetoacetate decreased significantly in ketotic cows; beta-hydroxybutyrate reduction was slower, especially in severely ketotic cows.

    Conclusions:

    • Dairy cows with ketosis exhibit impaired hepatic propionate utilization, affecting glucose homeostasis.
    • The rate of glucose production and ketone body clearance is compromised in ketotic cows.
    • Ketosis severity influences the dynamics of metabolic recovery following propionate challenge.

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