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3D Electrospinning of Macroscopic PLLA Structures.

Yvonne Tusiimire1,2,3, Michael Lubwama1, Robert Tamale Ssekitoleko4

  • 1College of Engineering, Design, Art and Technology, Makerere University, P.O Box 7062, Kampala, Uganda.

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Summary

Researchers developed 3D electrospun poly L-lactic acid (PLLA) structures with enhanced properties. These novel 3D PLLA biomimetic structures offer improved potential for various applications.

Keywords:
3D electrospinning3D fibrous macrostructuredefinitive Screening Designpoly L‐lactic acidtissue engineering

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Area of Science:

  • Biomaterials Engineering
  • Polymer Science
  • Nanotechnology

Background:

  • Traditional 2D electrospun nanofibers exhibit limitations in heavy metal sorption and mechanical strength.
  • Macroscopic 3D structures offer advantages like high porosity (99.992%) and larger pore sizes compared to 2D counterparts.

Purpose of the Study:

  • To fabricate macroscopic 3D poly L-lactic acid (PLLA) structures using 3D electrospinning.
  • To investigate the influence of various electrospinning parameters on the resultant 3D structure's dimensions and fiber characteristics.
  • To identify optimal conditions for producing uniform 3D PLLA structures.

Main Methods:

  • Fabrication of 3D PLLA structures via 3D electrospinning.
  • Systematic investigation of parameters including solvent system, polymer concentration, additive concentration (phosphoric acid), collector potential, working distance, flow rate, and nozzle voltage.
  • Optimization of electrospinning conditions to achieve desired fiber diameter and structural dimensions.
  • Characterization using Scanning Electron Microscopy (SEM) for fiber uniformity.

Main Results:

  • Identified optimal parameters for 3D PLLA structure fabrication: 0.5 wt.% phosphoric acid, 12 mg/mL PLLA solution, +1 V collector potential, +18 kV nozzle voltage, 4 cm working distance, 4 mL/h flow rate, and Dichloromethane/N,N-dimethylformamide (6:1) solvent.
  • Achieved a 3D PLLA structure with an average fiber diameter of 774 nm and a height of 2.36 cm.
  • SEM analysis confirmed uniform fiber distribution across different sections of the macroscopic 3D structures.

Conclusions:

  • Successful fabrication of macroscopic 3D PLLA structures via 3D electrospinning.
  • Demonstrated control over fiber diameter and structural dimensions by optimizing electrospinning parameters.
  • These findings broaden the application scope of PLLA in creating 3D electrospun biomimetic structures.