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Etching-Based Chiroplasmonic Sensing with Helicoid Au Nanocrystals for Anti-Interference Biochemical Detection
Xiaoxi Luan1,2, Fengxia Wu1, Xiali Lv1,2
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Small (Weinheim an Der Bergstrasse, Germany)
|May 12, 2025
Summary
Chiral plasmonic nanomaterials offer ultrasensitive detection. An H2O2-assisted etching method tunes their chiroptical activity for reliable sensing in complex samples, including glucose detection.
Area of Science:
- Nanotechnology
- Materials Science
- Analytical Chemistry
Background:
- Chiral plasmonic nanomaterials exhibit structure-dependent chiroptical activity, crucial for sensing.
- Developing tunable and robust chiroptical sensing platforms remains a challenge.
Purpose of the Study:
- To develop a tunable chiroptical sensing method using chiral helicoid gold (Au) nanocrystals.
- To demonstrate the application of this method for reliable detection in complex and colored samples, including glucose detection.
Main Methods:
- An H2O2-assisted etching strategy was employed to tune the size and morphology of chiral helicoid Au nanocrystals.
- Chiroptical signal response to morphological changes was leveraged for sensing.
- Glucose detection was achieved via glucose oxidase-catalyzed H2O2 production.
Main Results:
- Tunable chiroptical activity of helicoid Au nanocrystals was achieved by controlling etching parameters.
- The sensing method demonstrated excellent anti-interference performance in complex and colored sample matrices.
- Quantitative glucose detection in real colored samples confirmed the method's reliability and practical applicability.
Conclusions:
- The H2O2-assisted etching strategy provides a versatile approach for tailoring chiroptical properties of nanomaterials.
- Chiroplasmonic sensing based on helicoid Au nanocrystal etching shows significant potential for biochemical analysis and diagnostics in challenging environments.
