Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photobiomodulation-reprogrammed extracellular vesicles delivered <i>via</i> a biodegradable microneedle patch promote cardiac repair by enhancing glycolytic metabolism.

Acta pharmaceutica Sinica. B·2026
Same author

Bclaf1 drives heart failure by recruiting Srsf2 to enhance Hand2 pre-mRNA splicing and pathological hypertrophy.

Nature communications·2026
Same author

Unlocking the Prognostic Power of the m-CALLY Index in Cardiovascular-Kidney-Metabolic Syndrome.

Current medicinal chemistry·2026
Same author

Three-dimensionally printed mesoporous bioactive glass for craniomaxillofacial bone regeneration: Material evolution, functional mechanisms, and clinical translation.

Cell transplantation·2026
Same author

Huatuo Zaizao Pills improve myocardial ischemia by inhibiting extracellular calcium influx.

Chinese journal of natural medicines·2026
Same author

Identifying Key Pathogenic Mechanisms in Recurrent Glioblastoma Through Bioinformatics Analysis.

Current medicinal chemistry·2026

Related Experiment Video

Updated: May 11, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.0K

Adjuvant Anti-tumor Therapy with Polyphenolic Compounds: A Review.

Ilgiz Gareev1, Jianhao Jiang2,3, Ozal Beylerli1

  • 1Central Research Laboratory, Department of Pharmacology, Bashkir State Medical University, Republic of Bashkortostan, 3 Lenin Street, Ufa, 450008, Russia.

Current Medicinal Chemistry
|May 12, 2025
PubMed
Summary

Natural and synthetic polyphenols enhance cancer treatment by increasing oxidative stress in tumors and reducing resistance to chemotherapy and radiotherapy. They also protect normal tissues from treatment side effects.

Keywords:
Polyphenolschemotherapyprotective role.radiotherapyreactive oxygen speciesresistancesafetytreatmenttumors

More Related Videos

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.3K
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

319

Related Experiment Videos

Last Updated: May 11, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.0K
Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.3K
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

319

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Chemotherapy and radiotherapy combat cancer by inducing cell death via reactive oxygen species (ROS).
  • Increasing oxidative stress in tumor cells is a strategy to enhance anticancer therapy effectiveness.
  • Polyphenols are emerging as promising adjuvants in cancer treatment.

Purpose of the Study:

  • To explore the molecular mechanisms and clinical applications of polyphenols in cancer therapy.
  • To evaluate the role of polyphenols in reducing tumor cell resistance to chemo- and radiotherapy.
  • To investigate the protective effects of polyphenols against treatment-induced toxicity in normal tissues.

Main Methods:

  • Literature review of preclinical and clinical studies on polyphenols in cancer treatment.
  • Analysis of molecular pathways involved in polyphenol-mediated oxidative stress and cellular response.
  • Examination of data on polyphenol efficacy in combination with chemotherapy and radiotherapy.

Main Results:

  • Polyphenols demonstrate antitumor activity and enhance sensitivity to chemotherapy and radiotherapy.
  • Natural and synthetic polyphenols can mitigate the toxic side effects of cancer treatments on healthy tissues.
  • Polyphenols show potential in managing treatment-related toxicities, improving patient quality of life.

Conclusions:

  • Polyphenolic compounds offer a dual benefit in oncology: augmenting anticancer therapy efficacy and ameliorating treatment-induced toxicity.
  • Further clinical investigation into polyphenols is warranted for their integration into standard cancer care protocols.
  • Polyphenols represent a promising therapeutic strategy for improving outcomes in cancer patients undergoing chemo- and radiotherapy.