Related Experiment Video

Updated: May 13, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

14.2K

Obstetric and neonatal risks of Streptococcus agalactiae in adolescent pregnancy: a retrospective matched cohort

Jakub Staniczek1,2, Maisa Manasar-Dyrbus3,4, Rafal Stojko3,4

  • 1Chair and Clinical Department of Gynecology, Obstetrics and Gynecological Oncology, The Medical University of Silesia in Katowice, Poland. jstaniczek@sum.edu.pl.

Ginekologia Polska
|May 12, 2025
PubMed

Insights

Maternal age and pregnancy outcomes are influenced by Streptococcus agalactiae (GBS) status. Accounting for GBS colonization is crucial for accurately assessing age-related risks in pregnancy.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Streptococcus agalactiae (GBS) is a significant cause of obstetric and neonatal complications.
  • Adolescent pregnancy may impact GBS colonization rates and associated clinical outcomes.

Purpose of the Study:

  • To evaluate the influence of maternal age on obstetric and neonatal outcomes.
  • To specifically assess the modifying effect of GBS status on these associations.

Main Methods:

  • Retrospective matched cohort study of 582 participants (adolescents ≤ 19 years vs. older mothers > 19 years).
  • Propensity score matching was used for group selection.
  • Logistic and linear regression models were employed, adjusting for GBS interactions.

Main Results:

  • Unadjusted analyses showed higher risks of postpartum hemorrhage, uterine atony, and transient tachypnea of the newborn (TTN) in adolescent mothers.
  • These associations lost statistical significance after adjusting for GBS status.
  • Neonatal length also showed no significant association with maternal age after GBS adjustment.

Conclusions:

  • GBS colonization acts as a confounder in the relationship between maternal age and adverse obstetric/neonatal outcomes.
  • Accurate assessment of age-related pregnancy risks necessitates considering GBS status.
  • Clinical management strategies should incorporate GBS status for tailored care.
Abstract

Keywords:
GBSStreptococcus agalactiaeadolescent pregnancyhigh-risk pregnancyobstetrics complications

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.2K
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.2K

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.3K
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.1K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K