Related Experiment Video

Updated: May 14, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

144

Association between glycated hemoglobin and cognitive impairment in older adults with coronary heart disease: a

Wen Zheng1, Qin-Jie Xin1, Xiao-Xia Wang2

  • 1Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Journal of Geriatric Cardiology : JGC
|May 12, 2025
PubMed

Insights

High glycated hemoglobin (HbA1c) levels are linked to cognitive impairment in older adults with coronary heart disease (CHD). This finding may enhance cognitive screening for at-risk patients.

Area of Science:

  • Gerontology
  • Cardiology
  • Neurology

Background:

  • The link between glycated hemoglobin (HbA1c) and cognitive impairment in older adults with coronary heart disease (CHD) is not well understood.
  • Cognitive decline is a significant concern in aging populations, particularly those with cardiovascular conditions.

Purpose of the Study:

  • To investigate the association between glycated hemoglobin (HbA1c) levels and cognitive impairment in elderly patients diagnosed with coronary heart disease (CHD).
  • To determine if HbA1c is an independent risk factor for cognitive impairment in this demographic.

Main Methods:

  • A prospective cohort study was conducted with 3244 participants aged 65 years and older in Beijing, China.
  • Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).
  • Serum HbA1c levels were measured, and participants were categorized into high (≥ 6.5 mmol/L) and low (< 6.5 mmol/L) HbA1c groups. Logistic regression analyses were employed.

Main Results:

  • Elevated HbA1c levels were significantly associated with an increased risk of cognitive impairment in older adults with CHD.
  • Logistic regression confirmed HbA1c as an independent risk factor, whether treated as a continuous or categorical variable (OR = 1.27, 95% CI: 1.15-1.40; OR = 1.79, 95% CI: 1.41-2.26).
  • A linear relationship was observed between HbA1c levels and the risk of cognitive impairment (p for non-linear = 0.323).

Conclusions:

  • Higher glycated hemoglobin (HbA1c) levels are associated with a greater risk of cognitive impairment in elderly patients with coronary heart disease (CHD).
  • These findings suggest that monitoring HbA1c levels could aid in improving the accuracy and sensitivity of cognitive screening in this vulnerable population.
Abstract

Keywords:
HbA1ccognitive impairmentcoronary heart diseaseelders.

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

2.9K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.3K

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
30
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
486
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
336