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Updated: Jul 15, 2026
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Comprehensive evaluation of non-coding RNA-mediated autophagy regulation in myocardial ischemia-reperfusion injury
Zhongyang Song1,2, Chang Suo3, Yongqi Liu4
1Department of Oncology, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, China.
Abstract:
Ischemic heart disease remains a major global health challenge, with myocardial ischemia-reperfusion injury (MIRI) being one of its most common and severe pathophysiological complications. The pathogenesis of MIRI is multifaceted, involving oxidative stress, inflammatory responses, apoptotic pathways, and autophagic regulation. Notably, autophagy exerts a dual regulatory effect, where maintaining optimal autophagic flux is essential for cardiac homeostasis. Emerging evidence underscores the crucial role of non-coding RNAs (ncRNAs) in modulating these pathological processes. In particular, long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) have been identified as key regulators of autophagy-mediated MIRI progression through complex molecular networks. This review provides a systematic analysis of the molecular pathways through which ncRNAs influence MIRI pathogenesis, with a specific focus on their autophagy-regulatory mechanisms. These insights may enhance our understanding of MIRI pathobiology and facilitate the development of novel therapeutic strategies.
Insights
Myocardial ischemia-reperfusion injury (MIRI) involves complex pathways regulated by non-coding RNAs (ncRNAs). This review details how ncRNAs, including lncRNAs, miRNAs, and circRNAs, modulate autophagy in MIRI, offering therapeutic insights.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Genetics
Background:
- Ischemic heart disease poses a significant global health burden.
- Myocardial ischemia-reperfusion injury (MIRI) is a severe complication, driven by oxidative stress, inflammation, apoptosis, and autophagy.
- Autophagy plays a critical, yet complex, role in maintaining cardiac homeostasis during MIRI.
Purpose of the Study:
- To systematically review the molecular mechanisms of non-coding RNAs (ncRNAs) in MIRI pathogenesis.
- To elucidate the specific roles of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) in regulating autophagy during MIRI.
- To provide a comprehensive understanding of ncRNA-mediated autophagy in MIRI for potential therapeutic development.
Main Methods:
- Systematic literature review and analysis.
- Focus on molecular pathways linking ncRNAs, autophagy, and MIRI.
- Integration of findings on lncRNAs, miRNAs, and circRNAs.
Main Results:
- ncRNAs, including lncRNAs, miRNAs, and circRNAs, are key regulators of MIRI.
- These ncRNAs modulate critical pathological processes in MIRI, particularly autophagy.
- Complex molecular networks involving ncRNAs influence autophagy-mediated MIRI progression.
Conclusions:
- ncRNAs play a pivotal role in the pathogenesis of MIRI by regulating autophagy.
- Understanding these ncRNA-autophagy interactions is crucial for deciphering MIRI pathobiology.
- Targeting ncRNAs involved in autophagy may offer novel therapeutic strategies for MIRI.
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