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Published on: May 4, 2016
Effect of Gamma Rays on Adropin as a Potential Hepatokine Marker for Liver Damage in Male Albino Rats
Nadia Abdel-Magied1, Amira Mk Abouelella1, Hayam Mostafa1
1Department of Radiation Biology Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Egypt, Cairo.
Purpose:
This work was the first study to show the impact of γ- radiation on adropin levels in the serum and liver tissue of male albino rats.
Methods:
Liver tissue and blood samples of rats were collected at 1, 3, 7 and 14 days after whole-body exposure to 7.5 Gy of γ-radiation.
Results:
Irradiated groups revealed a marked decrease in adropin associated with a significant increase in STAT3 in the serum and gene expression. Furthermore, lipid profile (cholesterol, T.G, HDL, LDL, VLDL), liver function (AST, ALT, albumin and total protein), complete blood count (RBCs, WBCs, PLT, Hb, Hct%, MCH, MCV, WBCs differential), glucose and insulin were exhibited more noticeable alterations at all time periods of the experiment. In addition, data exhibited an obvious elevation in some inflammatory markers (IL-6) and TOS accompanied by a decline in the TAC.
Conclusion And Future Scope Of Work:
γ- radiation has adverse effects on adropin that related inversely with STAT3, leading to further damage to liver cells as well as disturbances in lipid and glucose metabolism. Therefore, adropin could be used in people exposed to radiation such radiotherapy to control the serious effects of radiation. Further study is needed to confirm these results.
