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Needle-Free Jet Injectors and Their Potential Applications in Plastic Surgery: A Review.

Neil M Vranis, Spero Theodorou

    Aesthetic Surgery Journal. Open Forum
    |May 12, 2025
    PubMed
    Summary
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    Needle-free jet injectors (NFJI) offer a safe and effective alternative to traditional needles for drug delivery. Studies show improved absorption, efficacy, and patient preference, with potential in plastic and dermatologic surgery.

    Area of Science:

    • Medical Devices
    • Drug Delivery Systems
    • Plastic Surgery Innovations

    Background:

    • Needle-free jet injectors (NFJI) are an established alternative for medication and vaccine delivery.
    • Despite proven benefits like faster absorption and efficacy, NFJI adoption in plastic surgery is limited.
    • Previous applications include botulinum toxin, steroids for scars, and local anesthesia.

    Purpose of the Study:

    • To review the clinical applications and efficacy of NFJI in plastic and dermatologic fields.
    • To assess the safety, mechanics, and patient preferences associated with NFJI technology.
    • To identify recent advancements and potential of NFJI in medical aesthetics.

    Main Methods:

    • Systematic literature review of studies published in the last 10 years, indexed on PubMed.

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  • Inclusion of original articles on ex vivo, animal, and human trials of NFJI devices.
  • Exclusion of review articles, theoretical modeling, and non-medical applications.

    • Main Results:

    • 115 articles met inclusion criteria from an initial 767 screened.
    • Majority of studies (53.9%) involved human patients, followed by animal and ex vivo models.
    • Investigations covered device efficacy, mechanics, safety, and patient acceptance, with improved outcomes.

    Conclusions:

    • NFJI devices represent a viable, safe, and potentially more effective delivery method than traditional needles.
    • NFJI technology demonstrates improved patient preference and reduced pain.
    • Significant potential exists for NFJI in plastic and dermatologic surgery applications.