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Updated: May 14, 2025
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Post-obstructive Acute Kidney Injury Due to a Retroperitoneal Mass
Zoraize Moeez Athar1, Mahnoor Arshad1, Gabrielle Davis2,1
1Internal Medicine, BronxCare Health System, New York City, USA.
Cureus
|May 12, 2025
Summary
This case report details a young woman with neurofibromatosis type 1 (NF1) who developed acute kidney injury (AKI) due to a retroperitoneal tumor. Prompt intervention with nephrostomy tubes successfully restored kidney function.
Area of Science:
- Nephrology
- Oncology
- Radiology
Background:
- Neurofibromatosis type 1 (NF1) is a genetic disorder that can lead to various tumors.
- Uterine fibroids are common benign tumors in women of reproductive age.
- Obstructive uropathy can cause acute kidney injury (AKI).
Observation:
- A 26-year-old woman with NF1 and uterine fibroids presented with symptoms of AKI.
- Diagnostic imaging revealed severe bilateral ureterohydronephrosis, indicating obstruction.
- A retroperitoneal tumor composed of fibroadipose and muscular tissue was identified.
Findings:
- Elevated creatinine and blood urea nitrogen (BUN) confirmed AKI.
- Bilateral nephrostomy tube placement led to significant improvement in renal function.
- Tumor biopsy showed fibroadipose and muscular tissue with inflammation.
Implications:
- Early recognition and radiological evaluation are crucial for managing AKI secondary to obstructive uropathy.
- Timely intervention, such as nephrostomy tube placement, can restore renal function.
- Further research is needed on managing AKI caused by primary retroperitoneal masses.
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