Hydroa Vacciniforme: A Rare Pediatric Photodermatosis.

Area of Science:

• Dermatology
• Virology
• Immunology

Background:

• Hydroa vacciniforme (HV) is a rare, chronic photodermatosis.
• It is frequently associated with Epstein-Barr virus (EBV) infection.

Observation:

• A 12-year-old child presented with a six-year history of recurrent vesiculobullous facial lesions and photosensitivity.
• Clinical examination showed hemorrhagic crusts and atrophic scars, with dermoscopy revealing whitish streaks and rosettes.
• Histopathology confirmed epidermal spongiosis and a dense dermal lymphoid infiltrate.

Findings:

• Immunohistochemistry identified CD3+, CD5+, CD7+, and CD8+ lymphocytes expressing granzyme B and perforin.
• EBV serology was positive, supporting the link to the virus.
• Differential diagnoses were excluded, confirming the diagnosis of HV.

Implications:

• The case highlights the importance of early diagnosis for Hydroa vacciniforme.
• Strict photoprotection is crucial for effective management and achieving sustained remission.
• This approach offers a viable strategy for patients with this rare photodermatosis.