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Updated: May 13, 2026

MALDI-Mass Spectrometric Imaging for the Investigation of Metabolites in Medicago truncatula Root Nodules
Published on: March 5, 2014
Mini Review: Highlight of Recent Advances and Applications of MALDI Mass Spectrometry Imaging in 2024
Yuen Tung Ngai1, Darren Lau1, Parul Mittal1
1UniSA Clinical and Health Sciences, Health and Biomedical Innovation University of South Australia Adelaide South Australia Australia.
Abstract:
Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) is an emerging imaging tool that allows visualisation of hundreds of analytes unbiasedly in a single experiment. This paper highlights the adaptations of MALDI-MSI in different context in 2024, such as clinical diagnostic, pharmacology, forensics applications, plant metabolism and biology. Challenges and advancements were also discussed regarding sample preparation, instrumentations, data analysis, and integration of machine learning in the trend of single cell resolution and multi-omics. There are still rooms for improvements in sensitivity, spatial resolution, acquisition algorithm and data integration across multi-omics data to enable MALDI-MSI at subcellular level.
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