Determining Factors Affecting the Successful Outcome of Fresh Embryo Transfer During In Vitro Fertilization: A...

Area of Science:

• Reproductive Medicine
• In Vitro Fertilization (IVF)
• Embryo Transfer Techniques

Background:

• Fresh embryo transfer rates are declining due to improved vitrification and concerns about ovarian hyperresponse.
• Clinical outcomes for fresh embryo transfer in normal responders are comparable to frozen embryo transfer.

Purpose of the Study:

• To identify key factors influencing the success of fresh embryo transfer.
• To analyze patient data, embryo quality, and procedural elements affecting pregnancy rates.

Main Methods:

• Retrospective cohort study of 521 women undergoing in vitro fertilization and fresh embryo transfer.
• Analysis of clinical data, embryo characteristics, endometrial factors, and transfer procedure details.
• Statistical analysis including chi-square, Fisher's exact test, t-test, and logistic regression.

Main Results:

• Overall clinical pregnancy rate was 17.1%.
• Advanced maternal age (>40 years) and day 3 embryo transfer were associated with significantly lower pregnancy rates.
• Good quality blastocyst transfer (≥322) increased the likelihood of clinical pregnancy compared to poor quality blastocysts.

Conclusions:

• Advanced maternal age and day 3 embryo transfer are significant predictors of reduced clinical pregnancy rates in fresh embryo transfer.
• Blastocyst quality is a critical factor for successful fresh embryo transfer outcomes.