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Updated: May 14, 2025

Characterization of SiN Integrated Optical Phased Arrays on a Wafer-Scale Test Station

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Optical Sensor Based on WS₂ Quantum Dots for Lamotrigine Determination.

Lina Hristova¹, Rut Martínez-Moro¹, Esperanza Fernández-García¹

¹Departamento de Química Analítica y Análisis Instrumental. Facultad de Ciencias. c/Francisco Tomás y Valiente, No 7. Campus de Excelencia de la Universidad Autónoma de Madrid, Madrid 28049. Spain.

|May 12, 2025

Summary

We developed a new optical sensor using tungsten disulfide (WS₂) quantum dots to detect lamotrigine, an antiepileptic drug. This sensor offers a sensitive and visual method for determining lamotrigine levels.

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Area of Science:

Materials Science
Nanotechnology
Analytical Chemistry

Background:

Tungsten disulfide (WS₂) quantum dots (QDs) are promising nanomaterials with unique optical properties.
Developing sensitive and selective methods for detecting pharmaceuticals like lamotrigine is crucial for therapeutic drug monitoring.

Purpose of the Study:

To synthesize WS₂ QDs using top-down and bottom-up approaches.
To investigate the fluorescence quenching interaction between WS₂ QDs and lamotrigine.
To develop and validate an optical sensor for lamotrigine detection.

Main Methods:

Synthesis of WS₂ QDs via liquid exfoliation and hydrothermal methods.
Spectroscopic characterization (UV-vis, fluorescence) and morphological analysis (AFM).
Development of an optical sensor by immobilizing WS₂ QDs on quartz and paper supports.

Main Results:

WS₂ QDs exhibited fluorescence quenching upon interaction with lamotrigine, with quenching intensity linearly proportional to concentration.
The optical sensor demonstrated a linear response in the 35.4–250 μM range with a limit of detection of 10.6 μM.
The sensor achieved 94% recovery in synthetic serum samples and showed potential for visual detection on paper.

Conclusions:

WS₂ QDs are effective fluorescent probes for lamotrigine detection.
The developed optical sensor provides a sensitive and reliable method for lamotrigine quantification.
Immobilization on paper offers a platform for rapid, visual, and point-of-care lamotrigine determination.