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Optical Sensor Based on WS2 Quantum Dots for Lamotrigine Determination.

Lina Hristova1, Rut Martínez-Moro1, Esperanza Fernández-García1

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This summary is machine-generated.

We developed a new optical sensor using tungsten disulfide (WS₂) quantum dots to detect lamotrigine, an antiepileptic drug. This sensor offers a sensitive and visual method for determining lamotrigine levels.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Tungsten disulfide (WS₂) quantum dots (QDs) are promising nanomaterials with unique optical properties.
  • Developing sensitive and selective methods for detecting pharmaceuticals like lamotrigine is crucial for therapeutic drug monitoring.

Purpose of the Study:

  • To synthesize WS₂ QDs using top-down and bottom-up approaches.
  • To investigate the fluorescence quenching interaction between WS₂ QDs and lamotrigine.
  • To develop and validate an optical sensor for lamotrigine detection.

Main Methods:

  • Synthesis of WS₂ QDs via liquid exfoliation and hydrothermal methods.
  • Spectroscopic characterization (UV-vis, fluorescence) and morphological analysis (AFM).
  • Development of an optical sensor by immobilizing WS₂ QDs on quartz and paper supports.

Main Results:

  • WS₂ QDs exhibited fluorescence quenching upon interaction with lamotrigine, with quenching intensity linearly proportional to concentration.
  • The optical sensor demonstrated a linear response in the 35.4–250 μM range with a limit of detection of 10.6 μM.
  • The sensor achieved 94% recovery in synthetic serum samples and showed potential for visual detection on paper.

Conclusions:

  • WS₂ QDs are effective fluorescent probes for lamotrigine detection.
  • The developed optical sensor provides a sensitive and reliable method for lamotrigine quantification.
  • Immobilization on paper offers a platform for rapid, visual, and point-of-care lamotrigine determination.