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Prevalence and Association of Insulin Resistance in Non-Diabetic Hemodialysis Patients: A Descriptive-Analytic

Bui Bao Hoang1, Khoa Ngoc Van Nguyen2, Trang Thi Khanh Ngo3

  • 1Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.

Indian Journal of Nephrology
|May 12, 2025
PubMed

Insights

Insulin resistance (IR) is common in hemodialysis (HD) patients, affecting over 60%. Higher BMI, anemia, dyslipidemia, and longer HD duration are linked to IR, impacting cardiovascular health.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Chronic kidney disease (CKD) patients face high cardiovascular disease (CVD) mortality.
  • Insulin resistance (IR) is a common CKD complication linked to worse cardiovascular outcomes.
  • This study focuses on IR prevalence and associations in hemodialysis (HD) patients.

Purpose of the Study:

  • To determine the prevalence of insulin resistance (IR) in hemodialysis (HD) patients.
  • To investigate associations between IR and various clinical factors in HD patients.
  • To understand the relationship between IR and cardiovascular risk factors in CKD.

Main Methods:

  • A cross-sectional study involving 103 HD patients.
  • Insulin resistance measured using Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI).
  • Analysis of associations between IR and factors including age, BMI, lipids, anemia, and HD duration.

Main Results:

  • High IR prevalence: 61.2% by HOMA-IR and 48.5% by QUICKI.
  • Significant associations found between IR and higher BMI, anemia, dyslipidemia, and longer HD duration.
  • No significant association between IR and age, gender, kidney failure etiology, or waist circumference.

Conclusions:

  • A high prevalence of insulin resistance (IR) exists in hemodialysis patients.
  • IR is significantly associated with BMI, anemia, dyslipidemia, and duration of HD therapy.
  • These findings highlight IR as a critical factor in managing cardiovascular risk in HD patients.
Abstract

Keywords:
HOMA-IRInsulin resistanceKidney failureQUICKI

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