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Therapeutic potential of fucoidan in atherosclerosis: a review
Qiujian Feng1,2, Jinye Ma3, Xuefan Jiang2,3
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. 313027694@qq.com.
Insights
Fucoidan, a seaweed polysaccharide, shows promise in combating atherosclerosis (AS) by improving lipid levels and reducing inflammation. This review explores its potential to protect against cardiovascular and cerebrovascular diseases.
Area of Science:
- Marine Biotechnology
- Cardiovascular Research
- Pharmacology
Background:
- Atherosclerosis (AS) is a progressive vascular disease linked to lipid metabolism, inflammation, and endothelial dysfunction, increasing risks of heart disease and stroke.
- Effective treatments for AS are crucial due to high incidence, mortality, and economic impact.
- Fucoidan, a polysaccharide from rockweed, exhibits properties relevant to AS pathophysiology.
Purpose of the Study:
- To systematically review the anti-atherosclerotic effects of fucoidan.
- To elucidate the underlying mechanisms of fucoidan's action against AS.
- To assess fucoidan's potential as a therapeutic agent for cardiovascular and cerebrovascular health.
Main Methods:
- Systematic review of recent scientific literature.
- Analysis of studies investigating fucoidan's impact on lipid metabolism.
- Evaluation of research on fucoidan's anti-inflammatory, antioxidant, and endothelial-protective properties.
Main Results:
- Fucoidan demonstrates significant lipid-lowering effects.
- It reduces vascular inflammation and enhances antioxidant defenses.
- Fucoidan provides protection to the vascular endothelium.
Conclusions:
- Fucoidan exhibits multifaceted anti-atherosclerotic properties.
- Its mechanisms include regulating lipid levels, reducing inflammation, and protecting the endothelium.
- Fucoidan is a promising candidate for preventing and treating atherosclerosis and related cardiovascular diseases.
Abstract:
Atherosclerosis (AS) is a slowly progressive disease that significantly increases the risk of cardiovascular diseases. The development of AS is closely associated with various factors, including disturbances in lipid metabolism, endothelial damage, inflammation, and the formation of unstable plaques. AS is strongly linked to diseases with high incidence and mortality, such as ischemic heart disease and stroke, which pose significant economic burdens. Recent studies have focused on identifying effective treatments for preventing and reversing AS. New evidence indicates that fucoidan, a polysaccharide derived from rockweed, possesses lipid-lowering, antioxidant, anti-inflammatory, endothelial-protective and prebiotic properties that align with the pathophysiology of AS, making it a promising therapeutic candidate. This review systematically presents recent progress in understanding the anti-atherosclerotic effects of fucoidan, particularly its underlying mechanisms. These mechanisms involve the regulation of lipid levels, reduction of vascular inflammation, enhancement of antioxidant defenses, and protection of the vascular endothelium. These insights are essential for improving cardiovascular and cerebrovascular health.
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