Related Experiment Video
Updated: May 13, 2025

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
Treatment-emergent central sleep apnea after initiation of hypoglossal nerve stimulator
Jonathan Tam1, Farnaz Abbasmoradi2, Lourdes M DelRosso2
1Department of Internal Medicine, University of California, Fresno, California.
Abstract:
Treatment-emergent central sleep apnea occurs when primary obstructive sleep apnea improves with positive airway pressure treatment, but central events emerge or persist. Although documented with positive airway pressure and other treatment modalities, emergence of central sleep apnea has rarely been reported with hypoglossal nerve stimulation. In this case report, we present 2 patients who developed central apnea during hypoglossal nerve stimulator titration with emergence of central events at higher voltages. Central apneas resolved in both patients at follow-up when maintained at stable voltages; however, in 1 patient, central apnea recurred upon trialing higher voltages. These cases demonstrate that treatment-emergent sleep apnea can also be considered as a potential consequence of treatment of obstructive sleep apnea with hypoglossal nerve stimulator.
Citation:
Tam J, Abbasmoradi F, DelRosso LM. Treatment-emergent central sleep apnea after initiation of hypoglossal nerve stimulator. J Clin Sleep Med. 2025;21(9):1639-1642.
Related Concept Videos
Sleep Apnea
The condition is more prevalent among...
Endotracheal Tube Extubation
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....
Hyperpnea and Hyperventilation
REM Sleep Behavior Disorder
RBD is significantly associated with...
Suctioning the Nasopharyngeal Airway
Equipment Required

