Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Acoustic analysis of changes in the lens layers after intravitreal dexamethasone implant injection].

Vestnik oftalmologii·2026

Same author

[Effect of a combined physiotherapeutic approach on changes in functional parameters after endovitreal surgery of rhegmatogenous retinal detachment with a favorable anatomical outcome].

Vestnik oftalmologii·2026

Same author

[Diabetic retinopathy and diabetic macular edema: etiopathogenesis and vitreoretinal surgery as one of the methods of treatment].

Vestnik oftalmologii·2026

Same author

[Angioid streaks of the retina: diagnosis and treatment].

Vestnik oftalmologii·2026

Same author

[Next-generation pharmaceutically acceptable vehicles for eye drops (preliminary report)].

Vestnik oftalmologii·2026

Same author

[Experimental assessment of mass transfer in the human cornea using cesium ion migration as a model].

Vestnik oftalmologii·2026

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Dissection of Human Vitreous Body Elements for Proteomic Analysis

Dissection of Human Vitreous Body Elements for Proteomic Analysis

Published on: January 23, 2011

[The effect of vitrectomy on changes in molecular biomarker levels of the vitreous cavity in the early postoperative

Yu Yusef^1,2, D V Petrachkov¹, K V Baryshev¹

¹Krasnov Research Institute of Eye Diseases, Moscow, Russia.

Vestnik Oftalmologii

|May 12, 2025

Summary

This summary is machine-generated.

Vitrectomy significantly reduced pro-inflammatory biomarkers in patients with proliferative diabetic retinopathy (PDR). This reduction highlights the vitreous body's role in biomarker accumulation in diabetic eye disease.

Keywords:

diabetic retinopathy molecular biomarkers multiplex assay vitrectomy

More Related Videos

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Published on: April 3, 2011

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

Published on: January 25, 2019

Related Experiment Videos

Last Updated: Jun 23, 2026

Dissection of Human Vitreous Body Elements for Proteomic Analysis

Dissection of Human Vitreous Body Elements for Proteomic Analysis

Published on: January 23, 2011

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Published on: April 3, 2011

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

Published on: January 25, 2019

Area of Science:

Ophthalmology
Molecular Biology
Biochemistry

Context:

Diabetic retinopathy (DR) pathogenesis involves complex molecular changes within the vitreous.
Understanding these biomarkers aids in optimizing treatment strategies for DR.
Multiplex assays offer advanced simultaneous analysis of numerous vitreous biomarkers, surpassing traditional ELISA methods.

Purpose:

To investigate alterations in vitreous biomarker levels in patients with proliferative diabetic retinopathy (PDR) post-vitrectomy.
To assess changes in pro-inflammatory cytokines and other molecular biomarkers in the early postoperative period following 25-gauge vitrectomy for PDR.

Summary:

This study analyzed vitreous samples from 24 patients with PDR before and one month after 25-gauge vitrectomy.
While vascular endothelial growth factor (VEGF) showed a non-significant decrease, significant reductions were observed in multiple pro-inflammatory biomarkers, including bFGF, IL-1β, and M-CSF.

Impact:

Vitrectomy effectively reduces the concentration of numerous pro-inflammatory biomarkers in the vitreous of PDR patients.
These findings underscore the vitreous humor's function as a reservoir for molecular mediators in diabetic retinopathy.
The study supports vitrectomy as a therapeutic approach that modulates the inflammatory milieu in PDR.