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Updated: May 13, 2025

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Published on: September 7, 2017
Old Habits Die Hard: DNA Methylation Patterns Persist in Experimental Transdifferentiation
Alice E Lord1, Leo J Dudley1, Lynette Graver1
1Centre for Haemato-Oncology, John Vane Science Centre, Charterhouse Square, Barts Cancer Institute, Queen Mary University of London, London, UK.
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The reprogramming of somatic cells into different lineages by transdifferentiation holds great promise for regenerative medicine and replacement therapies. However, a recent report by Radwan et al. (PNAS, 2024) finds that transdifferentiated cells fail to fully adopt the DNA methylation profiles of their new lineage. This has important implications regarding the viability of transdifferentiation as a strategy for cell replacement therapy.
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