Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

61.6K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
61.6K
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

70.1K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
70.1K
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

2.7K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.7K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

254
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
254
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

202
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
202

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Red Blood Cell Exchange Transfusion for Severe Babesiosis.

JAMA internal medicine·2026
Same author

Extending Sleep Improves Sleep and Stress Measures With Limited Microbiome Shift.

Journal of sleep research·2026
Same author

Tubulin polymerization dynamics are influenced by magnetic isotope effects consistent with the radical pair mechanism.

Science advances·2026
Same author

Guidance on the management of asymptomatic blood donors who test positive for Babesia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

A biphasic metabolism-β-lactamase production landscape governs the inoculum effect in β-lactamase-expressing <i>Escherichia coli</i>.

bioRxiv : the preprint server for biology·2025
Same author

The effect of gamma irradiation on the stability of vitamin D in select finfish species.

PloS one·2025
Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026
Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026
Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026
Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: May 21, 2025

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
07:20

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Published on: February 4, 2018

17.9K

Lyme Disease.

Robert P Smith1

  • 1Maine Medical Center, MaineHealth Institute for Research, Scarborough, Maine (R.P.S.).

Annals of Internal Medicine
|May 12, 2025
PubMed
Summary
This summary is machine-generated.

Lyme disease, a common tick-borne illness caused by Borrelia burgdorferi, presents with characteristic rashes and can lead to complications if untreated. Early antibiotic treatment is effective, though some patients experience persistent symptoms.

More Related Videos

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
08:23

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

13.1K
Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut
09:54

Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

Published on: February 14, 2011

11.5K

Related Experiment Videos

Last Updated: May 21, 2025

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
07:20

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Published on: February 4, 2018

17.9K
Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
08:23

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

13.1K
Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut
09:54

Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

Published on: February 14, 2011

11.5K

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Lyme disease is the most prevalent vector-borne illness in the U.S.
  • The geographic range of the tick vector is expanding.
  • Diagnosis often relies on erythema migrans rashes, but antibody testing has low initial sensitivity.

Purpose of the Study:

  • To summarize the key aspects of Lyme disease, including its cause, presentation, diagnosis, complications, and treatment.
  • To highlight the importance of early diagnosis and treatment in managing Lyme disease.
  • To acknowledge the challenges in diagnosis and the possibility of persistent symptoms post-treatment.

Main Methods:

  • Review of existing literature on Lyme disease.
  • Analysis of diagnostic criteria and testing sensitivities.
  • Examination of clinical manifestations and treatment outcomes.

Main Results:

  • Erythema migrans rashes are the hallmark of Lyme disease, varying in appearance.
  • Serologic testing for antibodies is less sensitive in early stages.
  • Neurologic, cardiac, and arthritic complications can arise from early dissemination or untreated disease.

Conclusions:

  • Lyme disease requires prompt diagnosis and effective antibiotic treatment.
  • Despite effective treatment, a subset of patients may experience persistent symptoms.
  • Continued surveillance and research are crucial due to the expanding tick vector range.