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Updated: May 16, 2025
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Causal relationship between cheese intake and periodontal diseases: A two-sample Mendelian randomization study
Zhijie Wu1, Chuanzhen Li2, Yujuan Yan1
1School of Stomatology, Hainan Medical University (Hainan Academy of Medical Science), Haikou, China.
Medicine
|May 12, 2025
Summary
Increased cheese consumption may reduce the risk of periodontal disease. This genetic study provides evidence that incorporating cheese into your diet could benefit periodontal health.
Area of Science:
- Oral health research
- Nutritional epidemiology
- Genetic research
Background:
- Dietary habits are known to influence periodontal disease risk.
- The specific impact of cheese intake on periodontal health remains largely undetermined.
Purpose of the Study:
- To investigate the potential causal relationship between cheese consumption and periodontal disease.
- Utilize Mendelian randomization (MR) analysis to assess this association.
Main Methods:
- Employed genome-wide association study (GWAS) data from the UK Biobank.
- Selected single nucleotide polymorphisms (SNPs) as instrumental variables for cheese intake.
- Applied various MR methods including Inverse-Variance Weighted (IVW) and MR-Egger, alongside sensitivity analyses for heterogeneity and pleiotropy.
Main Results:
- The IVW analysis indicated a significant inverse association between cheese intake and periodontal disease risk (OR = 0.545, P = 0.0032).
- Sensitivity analyses confirmed the robustness of these findings, showing no significant heterogeneity or horizontal pleiotropy.
Conclusions:
- Findings suggest that higher cheese intake is associated with a reduced risk of developing periodontal disease.
- This study offers genetic evidence supporting cheese as a potentially beneficial dietary component for maintaining periodontal health.
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