Related Experiment Video
Updated: May 14, 2025
An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
Published on: November 15, 2024
Evaluating safety and feasibility of same-day discharge after laser interstitial thermal therapy: a pilot study with
Adham M Khalafallah1, Nikola Susic2, Khushi H Shah2
1Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Adham.Khalafallah@jhsmiami.org.
Purpose:
Laser interstitial thermal therapy (LITT) is a minimally invasive treatment for intracranial tumors. Enhanced recovery after surgery (ERAS) protocols aim to optimize patient outcomes, and same-day discharge (SDD) is an emerging strategy to improve efficiency while maintaining safety. This pilot study evaluates the feasibility and safety of SDD following LITT.
Methods:
A retrospective review was conducted of patients who underwent LITT with planned SDD between May 2023 and June 2024 at our institution. Patients successfully discharged on the same day (study group) were match-paired 1:3 based on age, gender, and pathology, with patients discharged on post-ablation day 1 (control group) between January 2014 and April 2023. Demographic, perioperative, and treatment outcomes were compared.
Results:
SDD was achieved in 10 patients (mean age 56.80 ± 11.43 years, 70% males), compared to 30 controls (mean age 58.87 ± 12.23, 70% males). SDD patients had a significantly shorter observation period (p < 0.001). No differences were observed in postoperative edema (p = 0.640), midline shift (p = 0.195), Karnofsky Performance Status (KPS) at follow-up (p = 0.999), 30-day postoperative complications (p = 0.620), 30-day neurosurgical complications (p = 0.999), 30-day readmission (p = 0.584), 30-day neurosurgical readmission (p = 0.999), or 90-day mortality (p = 0.999) between groups.
Conclusion:
Our findings suggest that SDD following LITT is safe and feasible for appropriately selected patients. Rigorous patient selection and optimized perioperative protocols facilitate expedited recovery without compromising safety.
