Mental Health in Familial Adenomatous Polyposis: A Systematic Review
M J Mol1,2,3,4, H Bouchiba1,2,3, A S Aelvoet1,2,3
1Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Psycho-Oncology
|May 13, 2025
Summary
Familial adenomatous polyposis (FAP) patients may have higher rates of psychiatric disorders and intellectual deficits. Distress and anxiety symptoms can increase during genetic testing and surgery for this hereditary cancer syndrome.
Area of Science:
- Genetics
- Oncology
- Psychiatry
Background:
- Familial adenomatous polyposis (FAP) is an inherited condition with a near 100% risk of colorectal cancer without intervention.
- Lifelong surveillance and prophylactic surgery are standard for FAP patients, posing significant life challenges.
- Children of FAP patients have a 50% risk of inheriting the condition.
Conclusions:
- Some evidence suggests higher prevalence of psychiatric disorders and intellectual deficits in FAP patients compared to the general population.
- Distress, anxiety, and depressive symptoms may be elevated in specific FAP patient subgroups during key medical procedures.
- Due to the rarity of FAP and small sample sizes, further large-scale prospective studies are necessary to draw firm conclusions on mental health outcomes.
Keywords:
APC gene mutationSNP'scancercognitive functioningcolorectalco‐occurrent psychiatric disordersdisordersfamilial adenomatous polyposis (FAP)mental health issuesoncologyMore Related Videos
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