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Updated: May 14, 2025
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Prevalence and Significance of Pancreatic Iron in Transfusion-Dependent Sickle Cell Disease
Akhila Vadivelan1, Eamon Doyle2, Susan Carson3
1Department of Pediatrics, Division of Pediatric Hematology/Oncology, UCLA Mattel Children's Hospital, Los Angeles, California, USA.
Background:
Chronically transfused patients with sickle cell disease (SCD) and beta thalassemia major (TM) develop iron overload.
Objective:
Determine the impact of iron overload on glucose regulation in SCD.
Methods:
Prospective study of 28 patients with SCD and 38 patients with TM who underwent liver and pancreas R2* measurements and oral glucose tolerance tests.
Results:
Impaired fasting glucose (2 vs. 9, p = 0.27) and impaired glucose tolerance (1 vs. 11, p = 0.019) were less common in patients with SCD compared with patients with TM. No SCD patient had diabetes.
Conclusion:
Iron-mediated glucose dysregulation is present but less common in SCD patients.
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